CAS:1394076-92-6GNE-317

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GNE-317 Cat No. FB03152Cas No. 1394076-92-6

GNE-317 is a potent PI3K/mTOR inhibitor that can cross the blood–brain barrier and shows potent suppression of the PI3K pathway in the brain of mice with intact BBB.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4127 mL
- 12.0633 mL
- 24.1265 mL
- 5 mM
- 0.4825 mL
- 2.4127 mL
- 4.8253 mL
- 10 mM
- 0.2413 mL
- 1.2063 mL
- 2.4127 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

1394076-92-6

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C19H22N6O3S

运输

蓝冰

分子量

414.48

别名

溶解度

DMSO	19.0 mg/mL (45.8 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

描述GNE-317 is an optimized dual PI3K/mTOR inhibitor, which can cross the blood–brain barrier. Compared with the control group, a single oral dose of 50mg/kg GNE-317 significantly reduced pAkt, p4EBP1, and pS6 by 80%, 84%, and 92%, respectively, in the brain of normal mice at 1h post treatment. Oral administration of GNE-317 greatly inhibited GS2 brain tumor at 40mg/kg, daily for 6 weeks and U87 brain tumor at 40mg/kg, daily for 3 weeks, as well as prolonged survival of orthotopic GBM10 model.
动物研究
剂量
Mice: 50 mg/kg^[2] (p.o.)

给药途径
p.o.

动物研究
剂量	Mice: 50 mg/kg^[2] (p.o.)
给药途径	p.o.