CAS:114870-03-0Fondaparinux sodium

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Synonyms: Fondaparin sodium;SR-90107A

Fondaparinux sodium is a pentasaccharide inhibitor of antithrombin-dependent factor Xa (IC50 = 40 nM). It can bind to antithrombin III.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

114870-03-0

储存条件

分子式

C31H43N3Na10O49S8

运输

蓝冰

分子量

1728.08

别名

Fondaparin sodium;SR-90107A

溶解度

DMSO	90.0 mg/mL (52.1 mM)
Water	390.0 mg/mL (225.7 mM)

动物实验配方

生物活性

描述The activated serine protease Factor Xa (FXa), activated by both the intrinsic and the extrinsic pathways, plays a central role in the blood coagulation cascade. FXa catalyzes the conversion of prothrombin tothrombin through the prothrombinase complex. Fondaparinux Sodium is a pentasaccharide inhibitor of antithrombin-dependent factor Xa with IC₅₀ of 40 nM. Subcutaneous doses of 2.5 mg of fondaparinux once daily for at least five days reduced venous thromboembolism risk in patients undergoing surgery for fracture by 56.4 percent. Fondaparinux inhibited endogenous FXa activity in platelet-poor human plasma with IC₅₀ of 11 nM and 19 nM in rat plasma, whereas fondaparinux showed no significant inhibition of platelet-associated thrombin generation at the highest concentration tested (IC₅₀ >300 nM) in rat model of balloon injury.
作用机制Fondaparinux Sodium binds to antithrombin and induces a conformational change in the antithrombin molecule, creating an increased affinity for factor Xa and causing a several thousand-fold increase in the inhibition of factor Xa by antithrombin.