CAS:146-56-5Fluphenazine dihydrochloride

Synonyms: Prolixin

Fluphenazine 2HCl is a inhibitor of D1DR and D2DR. It has been used to deliver fluphenazine to biological systems and also used as an antipsychotic.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

146-56-5

储存条件

分子式

C22H28Cl2F3N3OS

运输

蓝冰

分子量

510.44

别名

Prolixin

溶解度

DMSO	250.0 mg/mL (489.8 mM) warming
Water	80.0 mg/mL (156.7 mM)

动物实验配方

0.5% CMC-Na

30 mg/mL

suspension

生物活性

描述Fluphenazine dihydrochloride is a phenothiazine-class D1DR and D2DR inhibitor; used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist^[3]. Dopamine receptor antagonists, including fluphenazine (0.1-1.0 mg/kg i.p.) prevented apomorphine- and lisuride-induced emesis but were less potent or had inconsistent actions to antagonise cisplatin- or ipecacuanha-induced emesis and failed to inhibit the emesis induced by copper sulphate^[4]. Fluphenazine can be an effective treatment for multiple tics in patients with dose-limiting side effects related to haloperidol^[5]. Fluphenazine treatment produced VCM (Vacuous chewing movements) in 70% of rats and the concomitant treatment with resveratrol decreased the prevalence to 30%, but did not modify the intensity of VCMs. Furthermore, the fluphenazine administration reduced the locomotor and exploratory activity of animals in the open field test. Resveratrol co-treatment was able to protect the reduction of both parameters^[6].