CAS:247257-48-3Fimasartan

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Fimasartan 非马沙坦 Cat No. FB09247Cas No. 247257-48-3

Synonyms: BR-A-657

Fimasartan is an improved non-peptide angiotensin II receptor blocker used for the treatment of hypertension and heart failure, which enables higher potency and longer duration than losartan.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9934 mL
- 9.9672 mL
- 19.9344 mL
- 5 mM
- 0.3987 mL
- 1.9934 mL
- 3.9869 mL
- 10 mM
- 0.1993 mL
- 0.9967 mL
- 1.9934 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

247257-48-3

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C27H31N7OS

运输

蓝冰

分子量

501.65

别名

BR-A-657

溶解度

DMSO	100.0 mg/mL (199.3 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Fimasartan (BR-A-657) is an angiotensin receptor II antagonist. Fimasartan displaced angiotensin II (Ang II) from its specific binding sites to AT1 subtype receptors in membrane fractions of HEK-293 cells with an IC50 of 0.16 nM. In conscious rats, Fimasartan (0.01, 0.1, 1 mg/kg; intravenously) dose-dependently antagonized Ang II-induced pressor responses. Fimasartan dose-dependently decreased mean arterial pressure in furosemide-treated rats and renal hypertensive rats. Fimasartan given orally at 1 and 3 mg/kg reduced blood pressure in conscious renal hypertensive rats^[2]. In addition, fimasartan down-regulates the expression of the iNOS (inducible nitric oxide synthase) in macrophages via NF-κB (nuclear factor-kappa B) and AP-1 (activator protein-1) inactivation^[3].