CAS:41340-25-4Etodolac

Etodolac is a non-selective inhibitor of COX with IC50 of 53.5 nM, it is a non-steroidal anti-inflammatory compound.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

41340-25-4

储存条件

分子式

C17H21NO3

运输

蓝冰

分子量

287.35

别名

溶解度

DMSO	200.0 mg/mL (696.0 mM)
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	4 mg/mL	clear
PO	0.5% CMC-Na	32 mg/mL	suspension

生物活性

描述Etodolac, a selective cyclooxygenase-2 (COX-2) inhibitor, is a non-steroidal anti-inflammatory drug. Etodolac contributes to protection against rejection after heart transplantation. Etodolac could therefore be used to suppress graft rejection by means of its anti-inflammatory properties^[3]. Etodolac is a nonsteroidal antiinflammatory drug (NSAID) that is available by prescription only and is used long term for therapy of chronic arthritis and short term for acute pain^[4]. The decrease in the paw-withdrawal threshold induced by paclitaxel was reversed by oral administration of etodolac at 10 mg/kg but was not affected by indomethacin, diclofenac, or celecoxib. The antiallodynic effect of etodolac gradually increased during repeated administration, and after 2 weeks the paw-withdrawal threshold at the preadministration point was significantly increased. Etodolac probably acts at the level of functional changes accompanying paclitaxel treatment, such as alterations in the activation state of components of the pain transmission pathway^[5].