CAS:571203-78-6Erastin

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Erastin Erastin Cat No. FB01114Cas No. 571203-78-6

Erastin is a compound that interacts with VDAC, blocks and reverses mitochondrial depolarization after microtubule destabilizers in intact cells and antagonized tubulin-induced VDAC blockage in planar bilayers. It is also a ferroptosis inducer.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8280 mL
- 9.1399 mL
- 18.2799 mL
- 5 mM
- 0.3656 mL
- 1.8280 mL
- 3.6560 mL
- 10 mM
- 0.1828 mL
- 0.9140 mL
- 1.8280 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

571203-78-6

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C30H31ClN4O4

运输

蓝冰

分子量

547.04

别名

溶解度

DMSO	18.0 mg/mL (32.9 mM)
Water	insoluble

动物实验配方

5%DMSO+40%PEG 300+5%Tween80+water

1.75 mg/mL

靶点数据

生物活性

描述Erastin is a both Ferroptosis activator and mitochondrial VDAC modulator. Erastin can trigger ferroptosis dependent upon intracellular iron. Treatment with 10μM Erastin for 6h can induce accumulation of cytosolic ROS which can be inhibited by 100μM deferoxamine in HT-1080 cells. Iron-dependent oxidative death and inhibition of System x^-_c can also be observed. Erastin can induce rapid, oxidative, non-apoptotic death in HRAS^V12-expressing cell lines at concentration below 1μM. This lethal effect of erastin is dependent on the RAS–RAF–MEK pathway for inhibition of MAPK, ERK1/ 2 or MEK1/2, or KRAS and BRAF knockdown could restore the lethality of erastin. This selectivity for cells with activated RAS–RAF–MEK signaling may due to the interaction of Erastin with VDAC proteins and the subsequent induction of mitochondrial dysfunction, release of oxidative species and, ultimately, non-apoptotic, oxidative cell death.
动物研究
剂量
Mice: 20 mg/kg^[2] (i.v.); 10 mg/kg, 30 mg/kg^[3] (i.p.), 40 mg/kg^[4] (i.p.)

给药途径
i.v., i.p.

动物研究
剂量	Mice: 20 mg/kg^[2] (i.v.); 10 mg/kg, 30 mg/kg^[3] (i.p.), 40 mg/kg^[4] (i.p.)
给药途径	i.v., i.p.