CAS:164650-44-6Efinaconazole

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Synonyms: KP-103

Efinaconazole is a triazole antifungal used to treat for onychomycosis, as it is a 14 alpha-demethylase inhibitor.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

164650-44-6

储存条件

分子式

C18H22F2N4O

运输

蓝冰

分子量

348.39

别名

KP-103

溶解度

动物实验配方

生物活性

描述Efinaconazole is a triazole antifungal agent. Efinaconazole has broad-spectrum antifungal activity against dermatophytes, nondermatophyte molds and yeasts, and high ungual penetration due to its low keratin binding properties^[3]. Efinaconazole againsts T. mentagrophytes SM-110 and C. albicans ATCC 10231 with MICs of 0.0039 μg/mL and 0.00098 μg/mL, respectively. Efinaconazole dose-dependently decreased ergosterol production and accumulated 4,4-dimethylsterols and 4α-methylsterols at concentrations below its MICs. Efinaconazole induced morphological and ultrastructural changes in T. mentagrophytes hyphae that became more prominent with increasing drug concentrations^[1]. Onychomycosis is a common but difficult to treat nail disorder. Both efinaconazole and combination with laser were efficacious treatment, but the combination therapy leads to quicker resolution with fewer rate of relapse^[4].