CAS:27220-47-9Econazole

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Econazole 益康唑 Cat No. FB06551Cas No. 27220-47-9

Synonyms: (±)-Econazole

Econazole is an imidazole-derived and broad-spectrum antimycotic agent with fungistatic properties, working by inhibiting biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.6200 mL
- 13.0999 mL
- 26.1997 mL
- 5 mM
- 0.5240 mL
- 2.6200 mL
- 5.2399 mL
- 10 mM
- 0.2620 mL
- 1.3100 mL
- 2.6200 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

27220-47-9

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C18H15Cl3N2O

运输

蓝冰

分子量

381.68

别名

(±)-Econazole

溶解度

DMSO	76.0 mg/mL (199.1 mM)

动物实验配方

靶点数据

生物活性

描述Econazole is an antifungal agent and a new PI3K (phosphatidylinositol-3-kinase) inhibitor and a potential drug that can be used in lung cancer treatment alone or in combination with cisplatin. Econazole significantly suppressed A549 tumor growth in nude mice^[3]. Guinea-pigs infected with T. mentagrophytes, M. canis or C. albicans and treated topically or orally with econazole, were cured. In each of these tests the activity of econazole was compared with that of different reference drugs. Vaginal candidiasis in rats was cured after oral administration of econazole. Toxicity and teratogenicity studies in different laboratory animals indicate that econazole is well tolerated^[4]. The econazole-bound TRPV5 (transient receptor potential vanilloid 5) structure adopts a closed conformation with a distinct lower gate that occludes Ca²⁺ permeation through the channel^[5]. Moreover, econazole nitrate loaded transethosomes are effective to deliver econazole nitrate transdermally in a controlled fashion for effective elimination of cutaneous candidiasis^[6].