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EB-3D is a novel potent and selective choline kinase ChoKα inhibitor with an IC50 of 1 μM. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells and induces senescence in breast cancer cell lines through the activation of the metabolic sensor AMPK and the subsequent dephosphorylation of mTORC1 downstream targets.
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18817579266
实验数据
技术信息
CAS号 | 1839150-63-8 | 储存条件 |
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分子式 | C30H36Br2N4O2 | 运输 | 蓝冰 | |||||||
分子量 | 644.44 | 别名 | ||||||||
溶解度 |
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动物实验配方 |
生物活性