CAS:130693-82-2Dorzolomide hydrochloride

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Dorzolomide HCl 盐酸杜塞酰胺 Cat No. FB01182Cas No. 130693-82-2

Synonyms: L671152 HCl;MK 507 HCl

Dorzolomide HCl is a potent and water-soluble inhibitor of human carbonic anhydrase II and IV with Ki of 1.9 nM and 31 nM respectively and used as anti-glaucoma agent.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7708 mL
- 13.8542 mL
- 27.7084 mL
- 5 mM
- 0.5542 mL
- 2.7708 mL
- 5.5417 mL
- 10 mM
- 0.2771 mL
- 1.3854 mL
- 2.7708 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

130693-82-2

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C10H17ClN2O4S3

运输

蓝冰

分子量

360.90

别名

L671152 HCl;MK 507 HCl

溶解度

DMSO	Insoluble
Ethanol	Insoluble

动物实验配方

靶点数据

生物活性

描述Carbonic anhydrase (CA) II, a physiologically predominant isoform in CA enzymes, is found in red blood cells and many other tissues and plays major roles in pH regulation of body, protection of electrolyte balance, transportation of water and some metabolic pathways^[3]. Dorzolamide hydrochloride, approved in patients with ocular hypertension or open-angle glaucoma, is a water-soluble, potent inhibitor of human CA II and CA IV in vitro, the respective IC₅₀ values being 0.18 nM and 6.9 nM. In contrast, it was found to be a much weaker inhibitor of human CA I (IC₅₀ value of 600 nM). In vivo, the topical administration of one 50 microliters drop of 0.5%, 1% and 2% solutions of dorzolamide maximally lowered the intraocular pressure (IOP) of glaucomatous monkeys by 22%, 30% and 37%, respectively. Good ocular hypotensive activity was also observed in ocular normotensive and hypertensive rabbits^[4]. Moreover, dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized the antitumor activity of mitomycin C in EAC (Ehrlich's ascites carcinoma) solid tumor models^[5].