CAS:89464-63-1DMOG

Synonyms: Dimethyloxallyl Glycine

Dimethyloxallyl glycine is a cell permeable, competitive inhibitor of HIF-PH (HIF-1α prolyl hydroxylase).

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

89464-63-1

储存条件

分子式

C6H9NO5

运输

蓝冰

分子量

175.14

别名

Dimethyloxallyl Glycine

溶解度

DMSO	400.0 mg/mL (2283.9 mM) warming
Water	510.0 mg/mL (2912.0 mM) warming

动物实验配方

生物活性

描述The family of HIF-PH (HIF prolyl hydroxylase) enzymes are the main molecular to regulate HIF activity through hydroxylation at 2 proline residues and cause the degradation of HIF, thus leading to inhibition on accumulation of functional HIF under normoxia. DMOG (Dimethyloxalylglycine) is a prolyl 4-hydroxylase inhibitor with IC50 value of 2 μM (measured by hydroxyproline formation in chicken embryo calvaria) ^[1]. HIF-1α is strongly induced in Hep3B and U2OS cells exposure to 100 μM or 1000 μM DMOG for 6h under normoxic culture conditions^[2]. Administration to newborn pups by i.p. injections at a dose of 200 mg/kg DMOG conferred a protective phenotype in the retinopathy of prematurity (ROP) model^[3].
作用机制DMOG, an analog to 2OG, can inhibit prolyl 4-hydroxylase in a competitive manner^[4]. It is the most structurally basic 2OG-derived HIF stabilizer^[3].
动物研究
剂量
Mice: 8 mg/Mice^[5] (i.p.); 20 mg/kg - 100 mg/kg^[6] (i.p.)

给药途径
i.p.