CAS:1818-71-9Crotonoside

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Crotonoside 巴豆苷 Cat No. FB09932Cas No. 1818-71-9

Synonyms: 2-Hydroxyadenosine;2-Oxoadenosine;2-Oxo-Ado

Crotonoside is a naturally occurring active isomer of guanosine found in the seeds of Croton tiglium, which could reduce the blood pressure in rabbits and cats.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5306 mL
- 17.6528 mL
- 35.3057 mL
- 5 mM
- 0.7061 mL
- 3.5306 mL
- 7.0611 mL
- 10 mM
- 0.3531 mL
- 1.7653 mL
- 3.5306 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

1818-71-9

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C10H13N5O5

运输

蓝冰

分子量

283.24

别名

2-Hydroxyadenosine;2-Oxoadenosine;2-Oxo-Ado

溶解度

DMSO	57.0 mg/mL (201.2 mM)

动物实验配方

靶点数据

生物活性

描述Crotonoside is isolated from Chinese medicinal herb, Croton and inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. In vivo, crotonoside treatment at 70 and 35 mg/kg/d produced significant AML tumor inhibition rates of 93.5% and 73.6%, respectively. Crotonoside (0 - 200 μM) selectively inhibits the viability of AML cell line MV4-11, MOLM-13 (with FLT3-ITD mutant) and KG-1 (without FLT3-ITD mutant) in a dose-dependent manner with an IC50 of 11.6 μM, 12.7 μM and 17.2 μM, respectively. Crotonoside (0 – 100 μM; 7 hours) inhibits the phosphorylation of FLT3. Erk1/2, Akt/mTOR and STAT5 is strongly inhibited by crotonoside at higher concentration of 12.5 μM in a concentration-dependent manner. Crotonoside (0 - 100 μM; 12 hours) exhibits a dose-dependent increase in the percentage of G0/G1 phase and a dose-dependent decrease in the percentage of G2/M and S phases cells^[3].