CAS:310460-39-04-(3-(2-Chlorophenyl)allylidene)-1-phenylpyrazolidine-3,5-dione

CPYPP 4-(3-(2-氯苯基)亚烯丙基)-1-苯基吡唑烷-3,5-二酮 Cat No. FB17552Cas No. 310460-39-0

CPYPP is a DOCK2 inhibitor which bounds to DOCK2 DHR-2 domain in a reversible manner and inhibited its catalytic activity in vitro. It also inhibits DOCK1 and DOCK5 and exhibits selectivity over DOCK9.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0792 mL
- 15.3959 mL
- 30.7919 mL
- 5 mM
- 0.6158 mL
- 3.0792 mL
- 6.1584 mL
- 10 mM
- 0.3079 mL
- 1.5396 mL
- 3.0792 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

310460-39-0

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C18H13ClN2O2

运输

蓝冰

分子量

324.76

别名

溶解度

DMSO	25.0 mg/mL (77.0 mM) warming

动物实验配方

靶点数据

生物活性

描述DOCK2 is an atypical Rac activator predominantly expressed in hematopoietic cells. CPYPP is a small-molecule inhibitor of DOCK2. It dose-dependently inhibited the nucleotide exchange factor activity of DOCK2^DHR-2 for Rac1 with an IC50 value of 22.8±2.4μM. DOCK2 overexpression-induced activation of Rac in HEK293T cells was significantly suppressed by one-hour pretreatment with CPYPP (100μM). Pretreatment of T cells or B cells with CPYPP at a concentration of 100μM for one hour almost completely inhibited Rac activation in response to CCL21 or CXCL13, respectively. One-hour treatment with CPYPP at 100μM inhibited TCR-mediated Rac activation in T cells. Treatment with 100μM CPYPP severely impaired CpG-A-induced Rac activation in pDCs. Intraperitoneal administration of mice with 5mg of CPYPP one hour before adoptive transfer reduced the percentage of migrated T cells to < 25% as compared to the control group^[1].
作用机制CPYPP is a small-molecule inhibitor of DOCK2 that reversibly binds to the DOCK2 DHR-2 domain and inhibited catalytic activity of DOCK2 in vitro^[1].