CAS:23593-75-1Clotrimazole

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Clotrimazole 克霉唑 Cat No. FB00413Cas No. 23593-75-1

Synonyms: BAY B 5097;FB-5097;CLT

Clotrimazole is a broad spectrum antimycotic or antifungal agent used to treat vaginal yeast infections, oral thrush, diaper rash, pityriasis versicolor, and types of ringworm including athlete's foot and jock itch.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8999 mL
- 14.4996 mL
- 28.9992 mL
- 5 mM
- 0.5800 mL
- 2.8999 mL
- 5.7998 mL
- 10 mM
- 0.2900 mL
- 1.4500 mL
- 2.8999 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

23593-75-1

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C22H17ClN2

运输

蓝冰

分子量

344.84

别名

BAY B 5097;FB-5097;CLT

溶解度

DMSO	11.0 mg/mL (31.9 mM)
Water	Insoluble
Ethanol	69.0 mg/mL (200.1 mM)

动物实验配方

靶点数据

生物活性

描述Clotrimazole is a broad-spectrum antimycotic drug mainly used for the treatment of Candida albicans and other fungal infections^[3]. In vitro, it is most active against Candida spp., Trichophyton spp., Microsporum spp. and Malazzesia fuffur (Pityrosporon orbiculare). In addition, it has some in vitro activity against certain Gram-positive bacteria, and at very high concentrations has activity against Trichomonas spp^[4]. The antimycotic drug clotrimazole inhibits the function of the gastric H,K-ATPase in a manner similar to that observed for the Na,K-ATPase^[5]. S. officinalis in the form of vaginal tablet, alone and when combined with Clotrimazole, can treat the Vulvovaginal Candidiasis^[6]. Moreover, thirty female Wistar rats with surgically implanted autologous endometrium were treated with CTZ (Clotrimazole) or vehicle (200 mg/kg) via esophageal gavage for 15 consecutive days. CTZ treatment significantly decreased the growth and the size of the implants, and histological examination indicated regression and atrophy, with no toxicity to the animals. CTZ promoted an overall amelioration of endometriosis in a rat model due to the anti-angiogenic properties of the drug^[7].