CAS:38083-17-9Climbazole

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Climbazole 甘宝素 Cat No. FB00958Cas No. 38083-17-9

Synonyms: BAY-e 6975

Climbazole is an imidazole antifungal agent used to manage dandruff in formulations such as shampoos or conditioners and as a preservative and a potent inducer and inhibitor of P450-dependent metabolizing enzymes.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4158 mL
- 17.0788 mL
- 34.1577 mL
- 5 mM
- 0.6832 mL
- 3.4158 mL
- 6.8315 mL
- 10 mM
- 0.3416 mL
- 1.7079 mL
- 3.4158 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

38083-17-9

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C15H17ClN2O2

运输

蓝冰

分子量

292.76

别名

BAY-e 6975

溶解度

DMSO	59.0 mg/mL (201.5 mM)
Water	Insoluble
Ethanol	59.0 mg/mL (201.5 mM)

动物实验配方

靶点数据

生物活性

描述Climbazole (CBZ) is used as an antifungal and preservative agent in many marketed formulations for the treatment of dandruff^[3]. Climbazole treatment of primary keratinocytes results in an upregulation in expression of a number of genes including those encoding proteins involved in cornified envelope formation. A climbazole-driven increase in cornified envelope proteins may improve the scalp skin barrier, which is known to be weaker in dandruff^[4]. Climbazole boosted retinoid activity both in the SE (skin equivalent) model, after a combined topic treatment with either retinol or retinyl propionate, and in vivo, in combination with a low level of retinol. Topical skin application of climbazole in combination with retinoids could deliver skin ageing benefits more than a less robust retinoid alone^[5]. Climbazole acts as a C14-demethylase inhibitor (DMI) fungicide and thus has a high efficacy against fungi. It was found that the toxicity of climbazole is mostly similar to that of other DMI fungicides, whereas it proved to be particularly toxic to primary producers. Reduction of frond size in water lentils and shoot length in higher plants suggested an additional plant growth-retarding mode of action of climbazole^[6].