CAS:127060-75-7CGP-42112

Synonyms: CGP 42112A

CGP-42112 is a potent Angiotensin-II subtype 2 receptor (AT2 R) agonist.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

127060-75-7

储存条件

分子式

C52H69N13O11

运输

蓝冰

分子量

1052.18

别名

CGP 42112A

溶解度

DMSO	350.0 mg/mL (332.6 mM)

动物实验配方

生物活性

描述Angiotensin II subtype 2 receptor (AT₂R) is abundantly expressed in adrenal medullary chromaffin cells^[2]. Recent data suggest that AT₂R may modulate key processes linked to atherosclerosis^[3]. CGP-42112 is a potent AT₂R agonist. CGP-42112 (≥ 1 nM) significantly inhibited cGMP production, TH-mRNA, TH-protein and TH-enzyme activity from the basal value, and these inhibitory effects were abolished by PD123319 (AT₂R antagonist). The [¹²⁵I] CGP-42112 binding was of high affinity, saturable and specific in the rat brain (combined olfactory bulb, septum, thalamus and midbrain) and whole adrenal^[4]. Intravenous infusions of CGP-42112 (0.1 and 1 mg/kg/min) shifted the upper limit of CBF (cerebral blood flow) autoregulation toward higher blood pressures without affecting baseline CBF^[5].