CAS:107233-08-9Cevimeline

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Cevimeline Cat No. FB09396Cas No. 107233-08-9

Synonyms: AF-102B;SNI 2011

Cevimeline is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors and used in the treatment of dry mouth associated with sjogren's syndrome.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.0172 mL
- 25.0862 mL
- 50.1723 mL
- 5 mM
- 1.0034 mL
- 5.0172 mL
- 10.0345 mL
- 10 mM
- 0.5017 mL
- 2.5086 mL
- 5.0172 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	107233-08-9	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C10H17NOS	运输	蓝冰
分子量	199.31	别名	AF-102B;SNI 2011

靶点数据

生物活性

描述Cevimeline is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. The excitatory effects of cevimeline on SSN (superior salivatory nucleus) neurons were mainly mediated by M1 and M3 receptors. Current-clamp recordings showed that application of cevimeline induced membrane depolarization (9/9 neurons). These results suggest that most SSN neurons are excited by cevimeline via M1 and M3 muscarinic receptors^[3]. Cevimeline at 80μmolkg(-1) showed slowly increasing and lasting salivation, a similar blood flow increment in the parotid gland and higher pressor response when compared to pilocarpine at 4μmolkg(-1). In parotid cells, cevimeline increased the intracellular Ca(2+) concentration in a similar manner to pilocarpine, but at a higher concentration than pilocarpine. Cevimeline inhibited angiotensin II-induced water intake and neuronal activity in the subfornical organ^[4]. Cevimeline specifically activates Na(+)/H(+) exchange and may promote Na(+) reabsorption by stabilizing epithelial sodium channel activity^[5].