CAS:23142-01-0Carbetapentane Citrate

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Carbetapentane Citrate 枸橼酸喷托维林,托可拉斯;妥克拉司 Cat No. FB09181Cas No. 23142-01-0

Synonyms: Pentoxyverine Citrate

Carβpentane citrate is a selective inhibitor of mAchR with Ki value of 76nM, also binds to serotonin 5-HT3 with Ki value of 7.9 nM and works as an agonist of the sigma-1 receptor (Ki = 10.4 nM).

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.9026 mL
- 9.5131 mL
- 19.0263 mL
- 5 mM
- 0.3805 mL
- 1.9026 mL
- 3.8053 mL
- 10 mM
- 0.1903 mL
- 0.9513 mL
- 1.9026 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

23142-01-0

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C26H39NO10

运输

蓝冰

分子量

525.59

别名

Pentoxyverine Citrate

溶解度

DMSO	98.0 mg/mL (186.5 mM)
Ethanol	8.0 mg/mL (15.2 mM)

动物实验配方

靶点数据

生物活性

描述Carbetapentane citrate, a non-opioid centrally-acting antitussive drug, is a common treatment for cough associated with other diseases such as common cold and respiratory tract infections. Its mode of action is very close to that of atropine; since it acts at the level of the peripheral parasympathetic nerve endings. The drug reaches its maximum plasma concentration (Cmax) 2h after administration, and it has a plasma half-life of 2.3h in case of oral administration^[3]. Carbetapentane exhibited dose-dependent spinal blockade with a more sensory-selective action over motor blockade. Carbetapentane showed a much stronger frequency-dependence of block than lidocaine: with high frequency stimulation (3.33 Hz), 50 µM lidocaine produced an additional 30% blockade, while the same concentration of carbetapentane produced 70% more block^[4]. Carbetapentane had an anticonvulsant action without protecting against NMDA-induced lethality^[5]. Carbetapentane pretreatment also significantly attenuated the KA-induced (kainic acid) increase in Fos-related antigen immunoreactivity in the hippocampus. Carbetapentane provides neuroprotection against KA insult via sigma-1 receptor modulation^[6].