CAS:10605-21-7Methyl 1H-benzo[d]imidazol-2-ylcarbamate

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Carbendazim 多菌灵 Cat No. FB08278Cas No. 10605-21-7

Synonyms: Mercarzole;Carbendazole

Carbendazim is a widely used, broad-spectrum benzimidazole fungicide with potential antimitotic and antineoplastic activities, used to control plant diseases in cereals and fruits.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 5.2305 mL
- 26.1524 mL
- 52.3049 mL
- 5 mM
- 1.0461 mL
- 5.2305 mL
- 10.4610 mL
- 10 mM
- 0.5230 mL
- 2.6152 mL
- 5.2305 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

10605-21-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C9H9N3O2

运输

蓝冰

分子量

191.19

别名

Mercarzole;Carbendazole

溶解度

DMSO	16.0 mg/mL (83.7 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

靶点数据

生物活性

描述Carbendazim (methyl 2-benzimidazolecarbamate) is widely used as a systemic fungicide in human food production and appears to act on fungal tubulin. However, it also inhibits proliferation of human cancer cells, including drug- and multidrug-resistant and p53-deficient cell lines, including murine melanoma, human breast, ovarian, lung, leukemia, and colon carcinoma cell lines, arresting the cells at the G2/M phase of the cell cycle and inducing apoptosis. It inhibits the proliferation of MCF7 human breast cancer cells with IC50 of 10 μM and arrests mitosis at a similar concentration (8 μM), in concert with suppression of microtubule dynamic instability without appreciable microtubule depolymerization. With microtubules assembled in vitro from pure tubulin, carbendazim also suppresses dynamic instability, reducing the dynamicity by 50% at 10 μM, with only minimal (21%) reduction of polymer mass. Carbendazim binds to mammalian tubulin (Kd, 42.8 ± 4.0 μM).