CAS:139481-59-7Candesartan

Synonyms: CV-11974

Candesartan is a benzimidazole-derived and competitive AT1 inhibitor with IC50 value of 0.26 nM.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

139481-59-7

储存条件

分子式

C24H20N6O3

运输

蓝冰

分子量

440.45

别名

CV-11974

溶解度

动物实验配方

2% DMSO+40% PEG 300+2% Tween 80+water

10 mg/mL

生物活性

靶点 Angiotensin Receptor

IC50:0.26nM
描述Candesartan is an angiotensin II receptor antagonist with IC₅₀ of 0.26 nM. In vivo research shows that conducted on 5XFAD mice, 2-months intranasal treatment with candesartan resulted in reduced Aβ deposits and microglial accumulation in the hippocampus but not in the cortex. In vitro, reduced IL-1β levels in 4-hour LPS-stimulated cortical microglia (100 ng/mL) following 2-hour pretreatment with candesartan (10 μM). It is a prolonged angiogenic effect, associated with enhanced VEGF-A and VEGF-B expression in vitro and in vivo, in response to a single dose of candesartan treatment.