CAS:314054-00-7C-176

Synonyms: STING inhibitor C-176

C-176 is a STING inhibitor with anti-inflammatory effection.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

立即询价

实验数据

技术信息

CAS号

314054-00-7

储存条件

分子式

C11H7IN2O4

运输

蓝冰

分子量

358.09

别名

STING inhibitor C-176

溶解度

DMSO	98.0 mg/mL (273.7 mM)
Water	insoluble

动物实验配方

生物活性

描述Stimulator of interferon genes (STING) is an intracellular signaling molecule that senses cytosolic DNA to regulate the production of type I interferons (IFNs) and other inflammatory cytokines. C-176 is a covalent STING inhibitor that effectively decreases STING-mediated IFNβ reporter activity at the dosage of 0.01 – 1.25 μM. Treatment of [³H]-palmitate labelled HEK293T cells with 1 μM C-176 inhibited STING palmitoylation. In wild-type C57BL/6J mice, pretreatment with 750 nmol C-176 for 1h and 4h resulted in a significant reduction of STING agonist-induced IFNs and IL-6 production in serum. Two-week injection of Trex1 deficient mice with C-176 (7.5 μL/day) significantly decreased serum levels of type I IFNs and suppressed cardiac inflammatory parameters. Treatment with C-176 in Trex1^-/- mice for three months attenuated systemic inflammatory signs in smooth muscle, tongue and stomach^[1].
作用机制C-176 is a nitrofuran derivative that acts as a STING inhibitor by covalently binding to the Cys91 of mouse STING^[1].