CAS:465-21-4Bufalin

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Bufalin 蟾毒灵 Cat No. FB08158Cas No. 465-21-4

Bufalin a major digoxin-like immunoreactive component of the Chinese medicine Chan Su and has been shown to exert a potential for anticancer activity against various human cancer cell lines in vitro.

规格	价格	促销价格	库存

18817579266

立即询价

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18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5872 mL
- 12.9358 mL
- 25.8716 mL
- 5 mM
- 0.5174 mL
- 2.5872 mL
- 5.1743 mL
- 10 mM
- 0.2587 mL
- 1.2936 mL
- 2.5872 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

465-21-4

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C24H34O4

运输

蓝冰

分子量

386.52

别名

溶解度

DMSO	77.0 mg/mL (199.2 mM)
Water	Insoluble
Ethanol	39.0 mg/mL (100.9 mM)

动物实验配方

靶点数据

生物活性

描述Bufalin is an active component isolated from Chan Su, acts as a potent Na+/K+-ATPase inhibitor, binds to the subunit α1, α2 and α3, with Kd of 42.5, 45 and 40 nM, respectively^[3]. Bufalin caused significant cytotoxicity in NCI-H460 cells at a concentration as low as 1 μM. DNA condensation was observed in bufalin-treated cells in a dose-dependent manner. Bufalin injected intraperitoneally in a dose-dependent manner reduced tumor size in BALB/C nu/nu mice implanted with NCI-H460 cells. Bufalin injection did not produce significant drug-related toxicity in experimental animals except at a high dose (0.4 mg/kg)^[4]. Bufalin-induced disruption of the SRC-1 (steroid receptor coactivator) isoform/ERβ (estrogen receptor) axis might induce apoptosis, pyroptosis and ERS (endoplasmic reticulum-stress) signaling in endometriotic lesions, causing the suppression of endometriosis^[5]. Bufalin inhibits cell proliferation and migration of HCC (hepatocellular carcinoma) cells via APOBEC3F induced intestinal immune network for IgA production signaling pathway^[6].