CAS:1022150-12-4Btk Inhibitor 1 R-Enantiomer

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Synonyms: Ibrutinib Intermediate

Btk inhibitor 1 R-enantiomer is a Btk kinase inhibitor.

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18817579266

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描述Btk inhibitor 1 R enantiomer is a pyrazolo[3,4-d]pyrimidine derivative as a Btk kinase inhibitor. Bruton's tyrosine kinase (BTK), a nonreceptor tyrosine kinase member of the Tec kinase family, is involved in B cell receptor(BCR) signalling and governs B-lymphocyte development, differentiation, signalling and survival. Ibrutinib is a covalent and irreversible inhibitor of Bruton's tyrosine kinase (BTK) and has been approved for the treatment of haematological malignancies. Ibrutinib irreversibly blocks BTK activity through covalent modification of Cys481. Btk inhibitor 1 R enantiomer can be used in synthesis of Ibrutinib and ibrutinib-based activity-based probes (ABPs).