CAS:1923833-60-6BMS-986205

您的位置 : 首页 / Metabolic Enzyme / IDO / BMS-986205

Synonyms: ONO-7701

BMS-986205 is a specific and irreversible inhibitor of IDO1 with IC50 value of 1.7 nM.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

1923833-60-6

储存条件

分子式

C24H24ClFN2O

运输

蓝冰

分子量

410.91

别名

ONO-7701

溶解度

DMSO	150.0 mg/mL (365.0 mM)
Water	insoluble

动物实验配方

生物活性

描述Indoleamine 2,3-dioxygenase 1 (IDO1) is a cytosolic enzyme involved in immune metabolism and inflammatory programing via the regulation in tryptophan catabolism. BMS-986205 is a selective, irreversible inhibitor of IDO1 that potently inhibits kynurenine production in IDO1-HEK293 cells with an IC50 value of 1.1 nM^[3]. BMS-986205 also displayed inhibitory effect on IDO1 in Hela cells with an IC50 value of 0.5 nM^[4]. In IFNγ SKOV-3 cells, BMS-98620 exhibited 80% maximum inhibition on IDO1 activity with an IC50 value of 9.5nM. IDO1-mediated blockage of Jurkat T cell activation was rescued by BMS-986205 with an IC50 value of 8nM. Incubation with BMS-98620 for 72 hours also induced Jurkar cell death with an IC50 value of 6.3M^[5].