CAS:1707289-21-1BLU-554

BLU-554 is a selective inhibitor of FGFR4 with the IC50 of 5 nM.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

1707289-21-1

储存条件

分子式

C24H24Cl2N4O4

运输

蓝冰

分子量

503.38

别名

溶解度

DMSO	100 mg/ml (198.66 mM)
Water	Insoluble

动物实验配方

生物活性

描述The fibroblast growth factor receptor 4 (FGFR4) is a member of the tyrosine kinase receptor family. BLU-554 is a potent, selective, oral FGFR4 inhibitor with an IC50 value of 5 nM. The IC50 values of BLU-554 for FGFR1, 2, and 3 are 624, 1202, and 2203 nM, respectively. In animals bearing Hep3B xenograft tumors, the treatment with BLU-554 at 100 mg/kg (b.i.d., p.o.) and 200 mg/kg (q.d., p.o.) for 20 days completed inhibited tumor growth compared to the vehicle control group. In the LIX-066 model, BLU-554 at 30 – 100 mg/kg (b.i.d., p.o.) suppressed tumor growth at 20-day post-treatment.
作用机制BLU-554 is a potent and highly selective FGFR4 inhibitor that covalently binds to FGFR4.