CAS:60628-96-8Bifonazole

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Bifonazole 联苯苄唑 Cat No. FB08884Cas No. 60628-96-8

Synonyms: BAY H 4502;Trifonazole

Bifonazole is a substituted imidazole antifungal agent, working by inhibiting the production of ergosterol, which is an essential component of fungal cell membranes.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.2217 mL
- 16.1087 mL
- 32.2174 mL
- 5 mM
- 0.6443 mL
- 3.2217 mL
- 6.4435 mL
- 10 mM
- 0.3222 mL
- 1.6109 mL
- 3.2217 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

60628-96-8

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C22H18N2

运输

蓝冰

分子量

310.39

别名

BAY H 4502;Trifonazole

溶解度

DMSO	50.0 mg/mL (161.1 mM) warming
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Bifonazole, a new broad-spectrum antimycotic, interferes with sterol biosynthesis. In contrast to clotrimazole, bifonazole possesses a sequential mode of action, namely inhibition of cytochrome P450-dependent C14-demethylation of sterols and direct inhibition of HMG-CoA-reductase^[3]. Bifonazole and clotrimazole are potent inhibitors of ergosterol synthesis in yeasts and dermatophytes. Inhibition of demethylation of 4,4',14-trimethylsterols is accepted as primary mode of action responsible for their fungistatic efficacy^[4]. Moreover, in PC3 human prostate cancer cells, bifonazole induced [Ca(2+)]i rises by inducing phospholipase C- and protein kinase C-dependent Ca(2+) release from the endoplasmic reticulum and Ca(2+) influx via non-store-operated pathways. Bifonazole (30-100 µM) induced apoptosis concentration-dependently^[5]. In the histamine wheal test and after UV radiation, Bifonazole showed antiphlogistic effects that were comparable to those of hydrocortisone^[6].