CAS:1233855-46-3BIA 10-2474

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BIA10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC50 of 4.9 nM.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

1233855-46-3

储存条件

分子式

C16H20N4O2

运输

蓝冰

分子量

300.36

别名

溶解度

动物实验配方

生物活性

描述Fatty acid amide hydrolase (FAAH), an integral membrane bound enzyme and a member of the extensive family of serine hydrolases referred to as amidase signature (AS) family, catalyses degradation of lipid signalling fatty acid amides including the sleep-inducing oleamide and endogenous cannabinoid anandamide (AEA). BIA10-2474 is an inhibitor of fatty acid amide hydrolase (FAAH) with IC₅₀ of 4.9 nM and shows IC₅₀ values of 50-70 mg/kg (i.p.) in various rat brain regions. BIA 10-2474 (50 mM) changed FAAH substrates (N-acylethanolamines), as well as several other lipid classes, including triglycerides, monoacylglycerols, (lyso) phosphatidylcholines, free fatty acids, and plasmalogens in human cortical neuron, which suggests BIA 10-2474 has the potential to cause metabolic dysregulation in the nervous system.