CAS:132-17-2Benztropine mesylate

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Benztropine Mesylate 甲磺酸苯扎托品 Cat No. FB09346Cas No. 132-17-2

Benztropine mesylate is a central muscarinic antagonist and a DAT inhibitor with IC50 of 118 nM, indicated for symptomatic relief of parkinsonism and drug-induced extrapyramidal reactions.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4781 mL
- 12.3905 mL
- 24.7810 mL
- 5 mM
- 0.4956 mL
- 2.4781 mL
- 4.9562 mL
- 10 mM
- 0.2478 mL
- 1.2390 mL
- 2.4781 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

132-17-2

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C22H29NO4S

运输

蓝冰

分子量

403.54

别名

溶解度

DMSO	500.0 mg/mL (1239.0 mM)
Water	100.0 mg/mL (247.8 mM)

动物实验配方

0.5% CMC-Na

60 mg/mL

clear

靶点数据

生物活性

靶点 DAT

IC50:118nM
描述Benztropine mesylate is a centrally acting anticholinergic agent for the treatment of Parkinson's disease. In a multiple sclerosis mouse model, benztropine mesylate induced the differentiation of oligodendrocytes through M1 and M3 muscarinic receptors and enhanced re-myelination. Benztropine mesylate also acts as an anti-histamine and a dopamine re-uptake inhibitor, and as an allosteric antagonist of the human D2 dopamine receptor. For 4T1-luc2 spheres, the IC₅₀ value of benztropine mesylate was around 5 μM. Benztropine (BZT) and its analogues inhibit dopamine uptake and bind with moderate to high affinity to the dopamine transporter (DAT). The BZT analogues showed a wide range of histamine H(1) receptor (K_i=16-37,600 nM) and DAT (K_i=8.5-6370 nM) binding affinities.