CAS:98-10-2Benzenesulfonamide

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Synonyms: Benzenesulphonamide;Benzosulfonamide;Phenyl Sulfonamide;Benzene Sulfonamide

Benzenesulfonamide ia an inhibitor of carbonic anhydrases.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

98-10-2

储存条件

分子式

C6H7NO2S

运输

蓝冰

分子量

157.19

别名

Benzenesulphonamide;Benzosulfonamide;Phenyl Sulfonamide;Benzene Sulfonamide

溶解度

动物实验配方

生物活性

描述Benzenesulfonamide is an inhibitor of human carbonic anhydrase B. Benzenesulfonamide derivatives are effective in the treatment of proliferative diseases such as cancer. Infection of HeLa cells was significantly inhibited by the oxazole-benzenesulfonamides, and the antiviral activity was most potent against replication stages before 8 h postinfection. Benzenesulfonamide inhibit intracellular HIV-1 reverse transcription and replication of WT HIV-1, as well as HIV-1 mutants that are resistant to current RT (reverse transcriptase) inhibitors^[3]. In vivo anti-inflammatory evaluation revealed that benzenesulfonamides bearing pyrazole moiety 19, 20 and its cyclized form 23 exhibited the highest anti-inflammatory activity with comparable potency to celecoxib. Benzenesulfonamide derivatives 19 and 20 displayed higher predicted binding affinities inside the COX-2 active site^[4].