CAS:57-37-4Benactyzine hydrochloride

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Benactyzine HCl 盐酸贝那替嗪 Cat No. FB07980Cas No. 57-37-4

Benactyzine HCl is a centrally acting mAchR antagonist, used in the treatment of depression and in research to investigate the role of cholinergic systems on behavior.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.7482 mL
- 13.7409 mL
- 27.4817 mL
- 5 mM
- 0.5496 mL
- 2.7482 mL
- 5.4963 mL
- 10 mM
- 0.2748 mL
- 1.3741 mL
- 2.7482 mL
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技术信息

CAS号

57-37-4

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C20H26ClNO3

运输

蓝冰

分子量

363.88

别名

溶解度

DMSO	70.0 mg/mL (192.4 mM)
Water	70.0 mg/mL (192.4 mM)
Ethanol	70.0 mg/mL (192.4 mM)

动物实验配方

靶点数据

生物活性

描述Benactyzine hydrochloride is a butyrylcholinesterase (BChE) inhibitor with a Ki of 0.010 mM. The inhibition of BChE by Benactyzine hydrochloride is pure or partial competitive^[1]. Large and significant decrements in visual function were demonstrated after the administration of benactyzine, particularly for those functions performed at near focus. The drug effect was rapid in onset, beginning 7-10 min after injection, peaked at approximately 30-40 min, and declined to baseline values over the next 2 h. The drug increased pulse rate and blood pressure, and induced an intoxicated state involving loss of concentration, attention, and short-term memory^[2]. Benactyzine hydrochloride increases the duration of the exploratory-motor reaction, but slightly diminishes the salivation elicited by acetylcholine. There is no blocking effect of Benactyzine hydrochloride and promazine on the EEG-seizure activity elicited by acetylcholine, and almost no inhibitory effect on emotional reactions. Promazine, and especially Benactyzine hydrochloride, inhibit and shorten the period of salivation elicited by the intra-amygdaloid injection of serotonin^[3].