CAS:335165-68-91-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol

BAI1 is an inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM).

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

335165-68-9

储存条件

分子式

C19H21Br2N3O

运输

蓝冰

分子量

467.20

别名

溶解度

DMSO	10.33 mg/mL (22.1 mM)
Water	insoluble

动物实验配方

生物活性

描述The Bcl-2 family is a group of anti- and pro-apoptotic proteins that plays essential roles in regulating programmed cell death. The activation of BAX, a pro-apoptotic member of the Bcl-2 family, is critical for the induction of mitochondrial outer membrane permeabilization. BAX activation inhibitor 1 (BAI1) dose-dependently inhibited tBID-induced BAX-mediated membrane permeabilization with an IC₅₀ value of 3.3 μM. The dissociation constant for BAI1 with BAX was 15.0 ± 4 μΜ. BAI1 dose-dependently inhibited tBID- and BIM SAHB-induced BAX membrane association and translocation with IC₅₀ values of 5 ± 1 and 2 ± 1 μΜ, respectively. In mouse embryonic fibroblasts, BAI1 inhibited TNF-α/cyclohexamide-induced apoptosis in a dose-dependent manner with an IC₅₀ value of 1.8 μM.
作用机制BAI1 demonstrated an inhibitory effect on BAX activation by binding directly to an allosteric site of BAX.