CAS:863031-21-4Azilsartan medoxomil

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Synonyms: TAK-491

Azilsartan Medoxomil is an orally available angiotensin II type 1 (AT1) receptor antagonist with IC50 value of 2.6 nM.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

863031-21-4

储存条件

分子式

C30H24N4O8

运输

蓝冰

分子量

568.53

别名

TAK-491

溶解度

动物实验配方

生物活性

靶点 Angiotensin Receptor 1

IC50:0.62nM
描述Azilsartan Medoxomil, a new angiotensin II Type 1 receptor blockers with IC50 of 0.62 nM. In conscious spontaneously hypertensive rats (SHRs), oral administration of 0.1-1mg/kg azilsartan medoxomil significantly reduced blood pressure at all doses even 24h after dosing. Azilsartan medoxomil, in 40 and 80 mg doses, combined with 5 mg of the calcium channel blocker amlodipine was well tolerated and led to meaningful additional BP(blood pressure) reductions compared with placebo plus amlodipine. Further, in aortic endothelial cells, azilsartan inhibited cell proliferation at concentrations as low as 1 μmol/l. Antiproliferative effects of azilsartan were also observed in cells lacking AT1(angiotensin II type 1) receptors.