CAS:1321514-06-0AZD4635

Synonyms: HTL-1071

AZD4635 is an A2AR antagonist which can reverse adenosine mediated T cell suppression.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

1321514-06-0

储存条件

分子式

C15H11ClFN5

运输

蓝冰

分子量

315.73

别名

HTL-1071

溶解度

DMSO	155.0 mg/mL (490.9 mM)
Water	insoluble

动物实验配方

生物活性

描述AZD4635 is an oral A2AR antagonist with Ki value of 1.7nM for affinity to human A2AR, > 30-fold selectivity over other adenosine receptors. AZD4635 inhibited cAMP production in CHO cells stably expressing human A2AR with IC50 values of 0.79, 10.0 and 142.9 nM in the presence of 0.1, 1 and 10 μM adenosine, respectively. AZD4635 reversed suppression and restored IFNγ secretion in cells incubated NECA, a stable analog of adenosine, in an ex vivo CD8+ T cell assay. AZD4635 led to a reduction in tumor growth alone and in combination with checkpoint inhibitors, and enhanced antitumor immunity as tumors harvested from the treated mice exhibited changes in infiltrating lymphocyte populations and increases in the functional activity of T cells.