CAS:1649-18-9Azaperone

Synonyms: NSC 170976;Fluoperidol

Azaperone functions as a dopamine antagonist that can bind to D1 and D2 receptors. It has the characteristics of antihistamines and anticholinergics.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

CAS号

1649-18-9

储存条件

分子式

C19H22FN3O

运输

蓝冰

分子量

327.40

别名

NSC 170976;Fluoperidol

溶解度

DMSO	330.0 mg/mL (1008.0 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	6 mg/mL	clear
PO	0.5% CMC-Na	62 mg/mL	suspension

生物活性

描述Administration of azaperone at weaning had a profound effect on preovulatory LH secretion as well as growth kinetics and estrogenicity of ovarian antral follicles^[3]. Thiafentanil and azaperone, with or without etorphine, delivered rapid safe, effective, reversible field anaesthesia in healthy swamp buffalo^[4]. Using azaperone alone the duration of immobility was 1.9 to 10.8 hours for mice and 0.9 to 2.4 hours for rats. The withdrawal reflex was not eliminated from mice receiving azaperone alone; however, the withdrawal reflex was eliminated from 0.9 to 2.4 hours in rats receiving azaperone. Azaperone produced a tachypnea in rats and male mice while a depressed respiratory rate was observed in female mice. Overall, azaperone alone was shown to provide sedation in mice as compared to a dose dependent anesthesia in rats. Azaperone and the azaperone-ketamine combination appear to be a suitable alternative to sedatives and anesthetics currently used in rats and mice^[5].