CAS:104987-12-4Ascomycin

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Ascomycin 长川霉素 Cat No. FB07816Cas No. 104987-12-4

Synonyms: FR 900520;Immunomycin;FK 520

Ascomycin is a naturally occuring macrolide produced by the fermentation of Streptomyces hygroscopicus and an ethyl analog of tacrolimus (FK506), exhibiting strong immunosuppressant properties.

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18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.2626 mL
- 6.3131 mL
- 12.6261 mL
- 5 mM
- 0.2525 mL
- 1.2626 mL
- 2.5252 mL
- 10 mM
- 0.1263 mL
- 0.6313 mL
- 1.2626 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

104987-12-4

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C43H69NO12

运输

蓝冰

分子量

792.01

别名

FR 900520;Immunomycin;FK 520

溶解度

DMSO	490.0 mg/mL (618.7 mM)
Water	insoluble

动物实验配方

靶点数据

生物活性

描述Ascomycin (FK520) is a macrocyclic antibiotic that also exhibits antifungal and immunosuppressive activity^[3]. Ascomycin (Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. IC50 values of FR-900520 for mouse mixed lymphocyte reaction was 0.55 nM. FR-900520, the major component, clearly prolonged skin allograft survival in rats^[4]. Ascomycin also had a 3-fold lower immunosuppressive potency in a popliteal lymph node hyperplasia assay, resulting in an equivalent therapeutic index consistent with a common mechanistic dependence on calcineurin inhibition. In 14-day studies, nephrotoxicity was not induced by continuous i.p. infusion of ascomycin at 10 mg/kg/day or daily oral administration (up to 50 mg/kg/day) in rats on a normal diet, nor by continuous i.v. infusion (up to 6 mg/kg/day) in rats on a low salt diet to enhance susceptibility^[5].