CAS:796-42-9AS-8351

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AS-8351 AS-8351 Cat No. FB11674Cas No. 796-42-9

AS8351 is a selective inhibitor of histone demethylase KDM5B (JARID1B) via competing for the chelated iron KDM5B needs and it can act as an iron chelator.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.4328 mL
- 17.1642 mL
- 34.3284 mL
- 5 mM
- 0.6866 mL
- 3.4328 mL
- 6.8657 mL
- 10 mM
- 0.3433 mL
- 1.7164 mL
- 3.4328 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

796-42-9

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C17H13N3O2

运输

蓝冰

分子量

291.30

别名

溶解度

DMSO	50.0 mg/mL (171.6 mM)

动物实验配方

靶点数据

生物活性

描述AS8351 works as a KDM5B inhibitor and efficiently induces cardiac reprogramming through combination with compound CHIR99021, BIX01294, AS8351, SC1, Y27632 and OAC2. This reprogramming induction effect of AS8351 may due to its targeting on KDM5B, which may facilitate this process and sustain the active chromatin marks (i.e., H3K4 methylation) at specific genomic loci.
作用机制AS8351 affects epigenetic modifications by competing with α-ketoglutarate for chelating iron/Fe(II) in certain epigenetic enzymes, such as the JmjC-domain-containing his-tone demethylases (JmjC-KDMs) that require α-KG and iron as co-factors.^[1]