CAS:99464-64-9Ampiroxicam

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Synonyms: CP 65703;Flucam;Nasil

Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

99464-64-9

储存条件

分子式

C20H21N3O7S

运输

蓝冰

分子量

447.46

别名

CP 65703;Flucam;Nasil

溶解度

DMSO	50.0 mg/mL (111.7 mM)
Water	insoluble

动物实验配方

生物活性

描述Ampiroxicam is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug. Ampiroxicam is a nonacidic ether carbonate prodrug of piroxicam. In an acute model of paw inflammation in rats, ampiroxicam is less potent than piroxicam itself: the ED50's of ampiroxicam are 9- and 3.5-fold higher than those of piroxicam following a single or multiple (5) daily oral doses, respectively^[3]. Ampiroxicam inhibits the stretching response in mice induced by phenylbenzoquinone (PBQ) with maximum protective effect (MPE) of 2 mg/kg. Ampiroxicam inhibits swelling in a dose-responsive manner in the rat foot edema (RFE) assay with ED50 of 28 mg/kg at single oral dose and 7.8 mg/kg at 5 daily oral dose. Ampiroxicam blocks primary and secondary lesion development in rat adjuvant arthritis with ED50 of 2.2 mg/kg and 0.5 mg/kg, respectively. Ampiroxicam (3.2 mg/kg) leads to a plasma concentration of 12 μg/mL at a Tmax of 2 hours in rats^[4]. Ultraviolet-A (UVA) -irradiated 1% Ampiroxicam sensitized in guinea pigs shows positive reaction in the patch testing to UVA-irradiated 1% Ampiroxicam and 1% thiosalicylate (TOS). Concentration of Ampiroxicam is easily reduced by the increase in UVA irradiation doses, as compared with that of piroxicam^[5].