CAS:1397-89-3Amphotericin B

Synonyms: NSC 527017

Amphotericin B is a polyene, antifungal antibiotic produced from a strain of Streptomyces nodosus.

规格	价格	促销价格	库存

18817579266

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咨询

18817579266

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实验数据

技术信息

CAS号

1397-89-3

储存条件

分子式

C47H73NO17

运输

蓝冰

分子量

924.08

别名

NSC 527017

溶解度

DMSO	50.0 mg/mL (54.1 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+30% PEG300+water	1 mg/mL	clear
PO	0.5% CMC-Na	36 mg/mL	suspension

生物活性

描述Amphotericin B (AmB) is the most effective drug for treating many life-threatening fungal infections. TLR2 (Toll-like receptors) and CD14 are required for amphotericin B-dependent inflammatory stimulation of innate immune cells and that TLR4 may also provide stimulation of these cells^[1]. AmB only kills unicellular Leishmania promastigotes (LPs) when aqueous pores permeable to small cations and anions are formed. At low concentrations (≤0.1 microM), AmB was found to be nonlethal against LPs but, above this concentration, leishmanias were rapidly killed^[3]. Amphotericin B treatment of hamsters infected with scrapie strain 263K prolongs the incubation period of the disease ^[4].