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AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks, with Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease. AMG 511 exhibits anti-tumor activity in mouse glioblastoma xenograft model .
规格 | 价格 | 促销价格 | 库存 |
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18817579266
实验数据
技术信息
CAS号 | 1253573-53-3 | 储存条件 |
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分子式 | C22H28FN9O3S | 运输 | 蓝冰 | |
分子量 | 517.58 | 别名 |
生物活性