CAS:6147-11-1alpha-Mangostin

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alpha-Mangostin α-倒捻子素 Cat No. FB01101Cas No. 6147-11-1

Synonyms: α-Mangostin

alpha-Mangostin is a dietary xanthone with broad biological activities, such as antioxidant, anti-allergic, antiviral, antibacterial, anti-inflammatory and anticancer effects. It is an inhibitor of mutant IDH1 (IDH1-R132H) with a Ki of 2.85 μM.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4363 mL
- 12.1815 mL
- 24.3629 mL
- 5 mM
- 0.4873 mL
- 2.4363 mL
- 4.8726 mL
- 10 mM
- 0.2436 mL
- 1.2181 mL
- 2.4363 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

6147-11-1

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C24H26O6

运输

蓝冰

分子量

410.46

别名

α-Mangostin

溶解度

DMSO	81.0 mg/mL (197.3 mM)
Water	Insoluble
Ethanol	82.0 mg/mL (199.8 mM)

动物实验配方

靶点数据

生物活性

描述Alpha-mangostin (α-mangostin), a natural xanthonoid, has antioxidant and anti-inflammatory properties. The IC50 values of α-mangostin in MCF-7 cells were 3.57 μM in 24 h and 2.74 μM in 48 h. As for MDA-MB-231 cells, the IC50 values were 3.35 μM in 24 h and 2.26 μM in 48 h. Alpha-mangostin induced breast cancer cells apoptosis in a dose-dependent manner, reaching very high levels at 4 μM concentration^[3]. In addition, α-mangostin significantly disrupted the integrity of mitochondria measured by loss of MMP (mitochondrial membrane potential) in a concentration-dependent manner^[4]. Alpha-mangostin is capable of improving insulin secretion in pancreatic β-cells and protecting cells from apoptotic damage^[5].