CAS:88321-09-9Aloxistatin

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Synonyms: E 64d;EP 453;EST

Aloxistatin is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

技术信息

CAS号

88321-09-9

储存条件

分子式

C17H30N2O5

运输

蓝冰

分子量

342.43

别名

E 64d;EP 453;EST

溶解度

DMSO	600.0 mg/mL (1752.2 mM) warming
Water	insoluble

动物实验配方

IP	2% DMSO+2% Tween80+40% PEG300+water	6 mg/mL	clear
PO	0.5% CMC-Na	36 mg/mL	suspension

生物活性

描述Cysteine proteases play multiple roles in basically all aspects of physiology and development. Furthermore, they are engaged in signalling pathways and in the response to biotic and abiotic stresses. Aloxistatin is a specific and potent inhibitor of cysteine proteinases isolated from a culture of Aspergillus japonicus. Aloxistatin at a series of concentrations was able to enter the intact platelet and inhibit the protease activity in lysed platelets when incubated for 5 min. After a brief preincubation with the membrane-permeable, Aloxistatin (10 mg/ml) blunted PTH-induced (parathyroid hormone) cell proliferation in sub-confluent cultures and also attenuated proliferation and inhibited differentiation in longer-term confluent cultures. Aloxistatin(100 mg/kg, p.o.) inhibited the activity of cathepsin B&L in skeletal muscle, heart, and liver of hamsters.
作用机制Aloxistatin reacts irreversibly with the thiol group at the active site.