CAS:29608-49-9Almitrine Mesylate

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Almitrine Mesylate 甲磺酸阿米三嗪 Cat No. FB07016Cas No. 29608-49-9

Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2+-dependent K+ channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.4931 mL
- 7.4654 mL
- 14.9307 mL
- 5 mM
- 0.2986 mL
- 1.4931 mL
- 2.9861 mL
- 10 mM
- 0.1493 mL
- 0.7465 mL
- 1.4931 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

29608-49-9

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C28H37F2N7O6S2

运输

蓝冰

分子量

669.76

别名

溶解度

DMSO	98.0 mg/mL (146.3 mM)
Water	Insoluble
Ethanol	100.0 mg/mL (149.3 mM)

动物实验配方

靶点数据

生物活性

描述Almitrine mesylate, a peripheral chemoreceptor agonist, inhibits selectively the Ca2+-dependent K+ channel. Almitrine at concentrations up to 10 mM did not affect whole-cell voltage-dependent K+, Ca2+, or Na+ currents in rat or rabbit cells. However, this concentration of almitrine significantly inhibited the Ca2+-dependent component of K+ currents in rat chemoreceptor cells. Almitrine inhibits the activity of a high-conductance (152±13 pS), Ca2+-dependent K+ channel by decreasing its open probability, with IC50 value of 0.22 μM. The inhibitory effect of almitrine on Ca2+-dependent K+ channels was also observed in GH3 cells^[1]. Almitrine acts via the peripheral arterial chemoreceptors raising carotid sinus nerve output and minute ventilation. Almitrine also has a pulmonary vascular action causing a dose-dependent constriction and dilatation. At low doses Almitrine enhances hypoxic pulmonary vasoconstriction and may improve the overall ventilation/perfusion ratio^[2].