CAS:612847-09-3AKT inhibitor VIII

您的位置 : 首页 / PI3K/Akt/mTOR / Akt / AKT inhibitor VIII

Synonyms: Akti-1/2

Akt inhibitor VIII is a allosterical and isozyme-selective Akt inhibitor with IC50 value of 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3.

规格	价格	促销价格	库存

18817579266

立即询价

咨询

18817579266

立即询价

实验数据

技术信息

生物活性

靶点 Akt3

IC50:2.12μM Akt2

IC50:210nM Akt1

IC50:58nM
描述Akt/PKB (protein kinase B) is a serine/threonine kinase which has a key role in the regulation of survival and proliferation. There are three isoforms of human Akt (Akt1, Akt2 and Akt3) and they all have an N-terminal PH (pleckstrin homology) domain and a kinase domain separated by a 39-amino-acid hinge region. AKT inhibitor VIII（Akti-1/2), a cell-permeable quinoxaline compound, is an non-ATP-competitive inhibitor with IC50s of 58 nM, 210 nM, and 2119 nM towards Akt1, Akt2, and Akt3, respectively. Akti-1/2 treatment induced an increase in NOXA protein levels and a down-regulation of the levels of MCL-1, a critical survival protein in chronic lymphocytic leukemia (CLL) cells, which indicated that Akti-1/2 might be a new therapeutic option for the treatment of CLL.