CAS:508186-14-91-(2,3-Di(thiophen-2-yl)quinoxalin-6-yl)-3-(2-methoxyethyl)urea

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Synonyms: ACSS2 inhibitor

Ac-CoA Synthase Inhibitor is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC50 of ~ 600 nM.

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18817579266

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18817579266

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实验数据

技术信息

CAS号

508186-14-9

储存条件

分子式

C20H18N4O2S2

运输

蓝冰

分子量

410.51

别名

ACSS2 inhibitor

溶解度

动物实验配方

生物活性

描述Acetyl-CoA represents a central node of carbon metabolism that plays a key role in bioenergetics, cell proliferation and the regulation of gene expression. The nucleocytosolic acetyl-CoA synthetase enzyme, ACSS2, supplies a key source of acetyl-CoA for tumors by capturing acetate as a carbon source. ACSS2 inhibitor (quinoxaline) is a reversible inhibitor of acetate-dependent acetyl-CoA synthetase 2 (ACSS2) with IC₅₀ of ~ 600 nM. This quinoxaline compound inhibits the ability of HepG2 cells to incorporate [14C]acetate into lipids with IC₅₀ of 6.8 μM, and also inhibits HepG2 utilization of [14C]acetate for histone acetylation with IC₅₀ of 5.5 μM.