CAS:1236188-16-1740 Y-P

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740 Y-P is cell-permeable peptide activator of PI3K.

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18817579266

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描述740 Y-P acts as a cell-permeable phosphopeptide activator of PI3K. It improved both the mitogenic response in C2 muscle cells and survival of cerebellar granule neurons at 50μg/ml, which can be inhibited by wortmannin and rapamycin. Correlated with its action on PI3K, the phosphorylation of Akt, which is an established downstream effector in the PI 3-kinase survival cascade, could be observed post 1h-treatment with 740 Y-P at the concentration of 25μg/ml. Pretreatment with 740 Y-P at 1.53 µM for 30min alleviated the cytolysis of cultured rat neurons induced by sera or IgG of children with Opsoclonus-myoclonus syndrome and neuroblastoma.
作用机制740 Y-P is a peptide that can mimic the phosphorylation of PDGF receptor and bind to the p85 SH2 domain with high affinity.