CAS:2022-85-75-Fluorocytosine

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5-Fluorocytosine 5-氟胞嘧啶 Cat No. FB04876Cas No. 2022-85-7

Synonyms: NSC 103805;Ro-2-9915

5-Fluorocytosine is an antimycotic prodrug which can be converted to 5-fluorouracil, working by inhibiting DNA and RNA synthesis and interfering with ribosomal protein synthesis. It shows both antifungal and antitumor activity.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.7464 mL
- 38.7319 mL
- 77.4638 mL
- 5 mM
- 1.5493 mL
- 7.7464 mL
- 15.4928 mL
- 10 mM
- 0.7746 mL
- 3.8732 mL
- 7.7464 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号

2022-85-7

储存条件

粉末: -20°C 3 年

液体: -80°C 12 月

分子式

C4H4FN3O

运输

蓝冰

分子量

129.09

别名

NSC 103805;Ro-2-9915

溶解度

DMSO	8.0 mg/mL (62.0 mM)
Ethanol	Insoluble

动物实验配方

靶点数据

生物活性

描述Flucytosine (5-FC, 5-Fluorocytosine) is a synthetic antimycotic compound. In combination with amphotericin B, 5-FC can be used to treat severe systemic mycoses, such as cryptococcosis, candidosis, chromoblastomycosis and aspergillosis. Moreover, 5-FC has been combined with newer azole antifungal agents; it also plays an important role in a new approach to the treatment of cancer. The severe side effects of 5-FC include hepatotoxicity and bone-marrow depression^[3]. 5-FC half-life in the serum of 10 rabbits increased from 3.35 +/- 0.27 to 24.63 +/- 0.70 hr after experimentally induced acute renal failure. Concentrations of 5-FC in the cerebrospinal fluid of five patients ranged from 17 to 62 mug/ml and were 74.4 +/- 5.6% of simultaneously determined serum concentrations^[4]. The 5FC-FCZ (fluconazole, FCZ) combination was antagonistic against Candida species, but for some Candida isolates synergism was found. For C. neoformans the interaction for both combinations was highly dependent on the tested isolate and the method used^[5].