CAS:22804-49-51-Hydroxy-2,3,5-trimethoxyxanthone

Synonyms: HM-1

1-Hydroxy-2, 3, 5-trimethoxyxanthone, a natural product isolated and purified from the herb of Halenia elliptica D.

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18817579266

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18817579266

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描述1-Hydroxy-2, 3, 5-trimethoxyxanthone, a natural product isolated and purified from the herb of Halenia elliptica D. Don, has vasodilator action ,which involves both an endothelium-dependent mechanism involving NO and an endothelium-independent mechanism by inhibiting Ca(2+) influx through L-type voltage-operated Ca(2+) channels. It can effectively inhibit the osteoclast differentiation in a co-culture system with mouse osteoblastic calvarial cells and bone marrow cells, it exhibits significant inhibition of osteoclast differentiation even at a low concentration (0.01 ug/mL) in a dose-dependent manner, and it can significantly reduce the pit formation on the dentine slice compared with the control group. It can protect mice from the acute lung injury induced by ipopolysaccharide (LPS), which is relative to the increasing of IκB-α protein expression and the suppressing of inducible nitric oxide synthase and cyclooxygenase-Ⅱ protein expression.