CAS:73069-25-7(±)-Praeruptorin A

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(±)-Praeruptorin A 白花前胡甲素 Cat No. FB10731Cas No. 73069-25-7

Synonyms: Praeruptorin-A

(±)-Praeruptorin A, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation, has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis, and can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro.

规格	价格	促销价格	库存

18817579266

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18817579266

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实验数据

储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.5880 mL
- 12.9401 mL
- 25.8802 mL
- 5 mM
- 0.5176 mL
- 2.5880 mL
- 5.1760 mL
- 10 mM
- 0.2588 mL
- 1.2940 mL
- 2.5880 mL
计算器摩尔计算器总药量计算器工作液计算器

技术信息

CAS号	73069-25-7	储存条件	粉末 -20°C 3 年液体 -80°C 12 月
分子式	C21H22O7	运输	蓝冰
分子量	386.40	别名	Praeruptorin-A

靶点数据

生物活性

描述(±)-Praeruptorin A, a natural product isolated and purified from the roots of Peucedanum praeruptorum Dunn., can exhibit its anti-osteoclastogenic activity by inhibiting p38/Akt-c-Fos-NFATc1 signaling and PLCγ-independent Ca(2+) oscillation, has the potential to inhibit migration/fusion of preosteoclasts in vitro and bone erosion in vivo by targeting calmodulin and inhibiting the Ca(2+)/calmodulin-CaMKIV-CREB-NFATc1 and/or Ca(2+)/calmodulin-calcineurin-NFATc1 signaling axis, and can significantly upregulate multidrug resistance-associated protein 2 expression via the constitutive androstane receptor-mediated pathway in vitro.