产品
编 号:F170371
分子式:C8H20N4O2
分子量:204.27
产品类型
结构图
CAS No: 146724-86-9
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产品详情
生物活性:
MAHMA NONOate is a NO donor. MAHMA NONOate effectively inhibits platelet aggregation induced by either collagen or ADP.
体内研究:
MAHMA NONOate (0.3-10 nmol/kg/min; i.v. once) shows both platelet inhibitory and vasodepressor effects in vivo.Animal Model:Male Wistar rats anaesthetised with pentobarbitone
Dosage:0.3-10 nmol/kg/min
Administration:Intravenous injection; 0.3-10 nmol/kg/min once
Result:Dose-dependently decreased in mean systemic artery pressure and showd a more potent effect than GSNO. Caused dose-dependent inhibition of the response to 0.3 μM/kg ADP.
体外研究:
MAHMA NONOate (0.1 nM-100 μM) dose-dependently inhibits platelet aggregation induced by either collagen or ADP.MAHMA NONOate shows inhibitory effects to pulmonary artery and platelet aggregation with log IC50 values of 7.18 and 6.16, respectively.