产品
编 号:F170266
分子式:C6H16N4O2
分子量:176.22
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5mg
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10mg
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25mg
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50mg
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生物活性:
PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.

体内研究:
PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound.Animal Model:Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound
Dosage:100 μM
Administration:Wounds received 100 μM PAPA NONOate in phosphate buffer
Result:Increased the wound healing rate in test group.

体外研究:
PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3.
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